A Peptide Targeted Contrast Agent Specific to Fibrin-Fibronectin Complexes for Cancer Molecular Imaging with MRI
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چکیده
منابع مشابه
A Peptide Targeted Contrast Agent Specific to Fibrin−Fibronectin Complexes for Cancer Molecular Imaging with MRI
A peptide targeted contrast agent, CLT1-(Gd-DTPA), was synthesized for molecular imaging of fibronectin-fibrin complexes in tumor tissue with magnetic resonance imaging (MRI). The T(1) and T(2) relaxivities of CLT1-(Gd-DTPA) were 4.22 and 4.45 mM(-1) s(-1) at 3 T, respectively. The targeted contrast agent specifically bound to tumor tissue and resulted in significant tumor contrast enhancement ...
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2008
ISSN: 1043-1802,1520-4812
DOI: 10.1021/bc800211r